Choice "C" is correct. A holder in due course (a holder who takes an instrument for value, in good faith, and without notice of any defenses, on or claims to, the instrument, and the instrument is a negotiable instrument/commercial paper) takes the instrument free from ordinary contract defenses and is subject to only certain defenses commonly known as known as "real" defenses. Breach of contract is an ordinary contract defense, not a real defense, and the maker/drawer cannot successfully raise against a holder in due course the defense of breach of contract.
Choice "b" is incorrect. Fraud in the execution (as opposed to fraud in the inducement) is a so-called real defense that may be raised against a holder in due course.
Choice "d" is incorrect. Discharge in insolvency is a so-called real defense that may be raised against a holder in due course.
Choice "a" is incorrect. Infancy, to the extent it is a simple contract defense, is a so-called real defense that may be raised against a holder in due course.